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Thermore, other receptors have been implicated in sensing S100 proteins, and these include G proteincoupled receptors,266,267 scavenger receptors 268,269 and cell surface heparan sulfate proteoglycans.270 It is important to note that similar to HMGB1 and IL-33, some S100 protein functions can be modulated by posttranslational modifications, such as oxidation.271?73 For example, S100A8/A9 are very

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